Tim Salomons at Le Pub Home Brew
Category: Basic Painscience
Lorimer Moseley Master Sessions Broadcast 2 – “LIVE”
Lorimer Moseley Master Sessions Broadcast 2 "LIVE"
Lorimer Moseley Master Sessions “LIVE”
Applied Neuroscience and the Paining Person (Course)
This is what happened at the Course
A Must listener – Stephen McMahon at PRF
Musings on the Progress of Pain Research: A Podcast with Stephen McMahon
You could spend 45 minutes in a whole bunch of worse ways…
“McMahon discusses his early days in the pain research field, what it was like to train with Patrick Wall, the gate control theory of pain, central sensitization, and much more”
“Not the smartness of people but the smartness of nature, I still think that there are many thinks to be discovered from the natural world that would greatly help in our efforts to develop analgesics”
Stephen McMahon
About Stephen McMahon
In this third IASP podcast features pioneering pain researcher Stephen McMahon, PhD. Dr. McMahon is Sherrington Professor of Physiology at King’s College London, UK, where he leads a research group in clinical neuroscience. He also directs the Wellcome Trust Pain Consortium, an international network of leading pain researchers. He trained under Patrick Wall at University College London before moving to King’s College London in 1985 to run his own lab. His major research interest is pain mechanisms, and he has been working to identify and understand pain mediators. More recently, he has focused on neuroimmune interactions and the role of genetics and epigenetics in pain.
Meet Dr. Kirsty Bannister
Biography
I lead the Bannister lab group, where we focus on the biological, pharmacological and anatomical basis of pain pathways and their plasticity in chronic pain states. Chronic pain affects up to 20% of the adult population and can occur in the presence or absence of any past injury or evidence of body damage. Modules that I teach on include Physiology and Pharmacology of the Central Nervous System, Pharmacology of Neurological and Psychiatric Disorders, Core Year One Fundamentals of Pharmacology, and Neuroscience. My lab’s research is funded by the Academy of Medical Sciences and the NC3Rs.
Please see my Research Staff Profile for more detail
Key publications:
- Kucharczyk et al., 2020. The impact of bone cancer on the peripheral encoding of mechanical pressure stimuli. Pain.
- Cummins et al., 2020. Activation of the descending pain modulatory system using cuff pressure algometry: Back translation from man to rat. European Journal of Pain.
- Bannister et al., 2019. Kappa opioid signaling in the right central amygdala causes hind paw specific loss of diffuse noxious inhibitory controls in experimental neuropathic pain. Pain
- Bannister et al., 2017. Multiple sites and actions of gabapentin-induced relief of ongoing experimental neuropathic pain. Pain
- Bannister et al., 2015. Diffuse noxious inhibitory controls and nerve injury: restoring an imbalance between descending monoamine inhibitions and facilitations. Pain
There is a great interview with Kirsty Bannister. Morten Hoegh is hosting Kirsty and talking basic neuroscience during the EFIC 2019. Click here
Central Nervous System Targets: Supraspinal Mechanisms of Analgesia
Central Nervous System Targets: Supraspinal Mechanisms of Analgesia
In the run up to Dr Kirsty Bannister’s Home Brew we will be sharing her work with you!
Pain care needs to understand and be able to integrate current discoveries in lab-based science.
Check out this article and drop your thoughts in the comments!
“Central Nervous System Targets: Supraspinal Mechanisms of Analgesia”
https://lnkd.in/etmcssz
Discovering novel & effective pain treatments
About the event
We are SO excited to welcome Dr. Kirsty Bannister to Le Pub
Kirsty will be talking about the reality of discovering novel and effective pain-relieving treatments through performing bench to beside translational research.
Chronic pain affects up to 20% of the adult population and can occur in the presence or absence of any past injury or evidence of body damage. ‘Nothing is more unique than our experience of pain and the idea that the same stimulus could evoke a different pain sensation in different individuals has always fascinated me’.
‘There have been great improvements in our understanding of pain physiology and pathophysiology over the years, but why hasn’t this translated to a met clinical analgesic need? By discussing the ways in which we currently assess nociception and pain in non-human and human experimental models, we will slowly unravel the intricacies and challenges of treating persistent pain in varied patient groups’.
This is going to be an incredible Le Pub Homebrew!
World Event Times
London, Thursday, 18 March 2021, 20:00 GMT
Amsterdam, Thursday, 18 March 2021, 21:00 CET
New York, Thursday, 18 March 2021, 16:00 EDT
Dr. Kirsty Bannister
Kirsty Bannister is a Lecturer in the Institute of Psychiatry, Psychology and Neuroscience at Guy’s campus, King’s College London. Kirsty does research in neuropharmacology.
Kirsty leads the Bannister lab group, where she focuses on the biological, pharmacological and anatomical basis of pain pathways and their plasticity in chronic pain states. Modules that she teaches on include Physiology and Pharmacology of the Central Nervous System, Pharmacology of Neurological and Psychiatric Disorders, Core Year One Fundamentals of Pharmacology, and Neuroscience.
Cancellation Terms
Places can be cancelled and refunded up to 48 hours before the start of the event. Within 48 hours of start time no refund.
Recordings
Please note that Le Pub Home Brew is a LIVE EVENT. We are looking at options for giving access to recordings in the future, but right now, we are doing what we are best at – bringing you awesome live and interactive learning events!
Find out when exercise will help or hinder when you’re experiencing pain
Find out when exercise will help or hinder when you're experiencing pain
About this event
Exercise is a recommended treatment for those with chronic pain. However, individuals with chronic pain have significant pain during activity that can interfere with exercise treatments. We will discuss the underlying neurobiology for how physical activity increases and decreases pain, the clinical implications of these findings, and how treatment with TENS can reduce movement-evoked pain.
World Event Times
London, Thursday, 18 February 2021, 20:00:00 GMT
Amsterdam, Thursday, 18 February 2021, 21:00:00 CET
New York, Thursday, 18 February 2021, 15:00:00 EST
Kathleen A. Sluka, PT, PhD, FAPTA
Professor of Physical Therapy and Rehabilitation Science
Dr. Sluka’s laboratory studies the peripheral and central mechanisms of chronic musculoskeletal pain, and non-pharmacological treatment for chronic pain. These studies involve the use of animal models of muscle pain developed and characterized in Dr. Sluka’s laboratory, as well as projects in human subjects. We use a variety of techniques to address these questions including cell culture, molecular biology, genetic manipulations, behavioral pharmacology, and standard clinical trial methodology. Our overall goals are to improve the management of pain for people with a variety of musculoskeletal pain conditions by discovering the underlying mechanisms that lead to the development of chronic pain, discovering new therapies for pain management, and improving the use of currently available treatment for pain.
Cancellation Terms
Places can be cancelled and refunded up to 48 hours before the start of the event. Within 48 hours of start time no refund.
Recordings
Please note that Le Pub Home Brew is a LIVE EVENT. We are looking at options for giving access to recordings in the future, but right now, we are doing what we are best at – bringing you awesome live and interactive learning events!
Pain, hyperalgesia and activity in nociceptive C units in humans
Pain, hyperalgesia and activity in nociceptive C units in humans
Synopsis
Check out this great bit of work by LaMotte et al from 1992.
Here’s some simple reflections of the science:
– First they’re exploring activity of nociceptors in humans. That means someone volunteered for this!
– They use a crude way of ‘finding’ C-mechanoheat nociceptive units (CMHs) – scrape the skin or pinch it between the fingers
– It is only classified as a C-fibre if the conduction velocity is less than 2 m/s
– It is only classified as mechanoheat nociceptor if it selectively responds to technical or heat stimuli which typically cause pain
– They carefully map the receptive field
– Then they inject capsaicin i.e. the active component of chili peppers
– Interestingly, they tried to limit the numerical rating scale of pain to sensation only (is it possible to separate yourself from the unpleasantness or tolerability?)
What did they find?
– Heat and pain threshold reduced after injecting capsaicin. Now temperatures as low as 30C were felt as painful!
– Cooling the skin reduced pain and the spontaneous firing of the CMHs
– Warming increased this again!
– There was evidence of mechanical hyperalgesia i.e. increased pain to mechanical stimuli
– Some of this was outside of the skin zone affected by the injection i.e. ‘secondary hyperalgesia’
– There was evidence of analgesia around the injection site too
A simple summary:
– Ask a bunch of crazy people if it’s ok to inject some chili into them
– Scrape, pinch, electrically stimulate, heat and cool them whilst asking if it hurts
– Find that the injection makes these things simultaneously hurt more or less depending on where you do it
– Then discover something totally cool but keep in under wraps
Here’s the cool discovery – hang in there!
“A few presumably chemosensitive C units were discovered serendipitously during studies of CMH units….” In other words, it looks like these researchers were (?) the first to discover sleeping or silent nociceptors in humans. BOOM
It’s worth hearing their summary and considering some of the current proposed models to understand pain with.
“An interesting question is why pain from intradermal injection of [capsaicin] is so intense….One possible explanation might be that the discharge pattern in C polymodal nociceptors on capsaicin injection is irregular, with bursts of impulses …. It is conceivable that such high instantaneous firing rates during bursts of impulses could give rise to considerable pain due to temporal summation….It is also possible that several types of nociceptors are activated by capsaicin. Candidate nociceptors in addition to the CMHs could include purely chemosensitive units as well as the heat nociceptors that respond both to noxious heat and to capsaicin but not to mechanical or cold stimuli.”
Enjoy!
Research papers
You can access Lemotte’ paper here